Astma, allergi och KOL

Huvudansvariga är Björn Ställberg och Karin Lisspers.
Nedan presenteras ett urval av projekt på engelska.

The PRAXIS-study asthma/COPD 

The aim of the PRAXIS-study is to compare asthma and COPD guidelines with the actual care. The study started 2005 and is based on questionnaires and record examination. Several reports have been published. A follow-up study started in 2012 with new longitudinal data from the cohort of asthma and COPD patients from 2005. In 2014 a new random selection of both asthma and COPD-patients was performed.

The physicians’ actions in the management of COPD

The aim of this project is to study how quality of care for patients in primary care with COPD can be improved by better understanding of the prevalence, indicators, and physicians’ actions.

The ARCTIC study

Patient characterization, costs and outcomes in a COPD population based on a tailored and integrated EMR and registry data in Sweden. The purpose of this research study was to generate evidence related to COPD patients in Sweden, focusing on early diagnosis treatment, management, outcomes and costs of COPD. The study is performed in cooperation with Novartis.

Comorbidities of patients diagnosed with COPD and asthma and effectiveness of Spiromax in real life in Sweden

The overall purpose of this research study is to obtain real-world evidence from Swedish national registries on comorbidities that may affect handling of inhalers and devices. The objective of the study is to describe the co-morbidity patterns in asthma and COPD, in terms of age, gender, region of residence and COPD and asthma treatments. Linkage of three national health registers: Swedish Prescription Registry, Swedish Patient Registry and Swedish Cause of Death Registry will be done. The national population based cohorts in Sweden including 694,900 COPD and asthma patients. We also describe the overall health by using the uniform Charlson comorbidity index. The comorbidities will also be presented separately for COPD and asthma patients, and also for patients with both COPD and asthma documented in the registers. The study is performed in cooperation with Teva. 

Treatment of asthma in primary health care using exhaled nitric oxide analysis

The aim is to examine whether use of exhaled nitric oxide (NO) to guide anti-inflammatory treatment can improve asthma-related quality of life in adult patients with allergic asthma. The data have been collected and are being processed. The same study is examining whether there is an association between different circulating cytokines (systemic inflammation), exhaled NO and quality of life. The project is receiving financial support from Karolinska Institutet. 

The PATHOS study

This is a retrospective epidemiological study to map outpatients with COPD and describe COPD health care in real-life primary care during the first ten years of the 21st century. Data has been extracted anonymously from electronic patient records in primary care on approximately 25,000 patients. In addition, data regarding morbidity and mortality has been collected from the Hospital Discharge Register (Slutenvårdsregistret) and the Cause of Death Register and information on prescribed drugs was collected from the Prescription Register. Data on social-economic status has also been collected from Statistics Sweden (SCB).
The PATHOS study is receiving financial support from AstraZeneca. The data management has been performed by Pygargus and Uppsala Clinical Research Centre.

The TIE study - How can COPD patients with risk for exacerbations be identified? 

A new prospective study in primary and secondary care in collaboration with the Clinical Research Centre in Gävle and the Department of Medical Sciences: Respiratory Medicine & Allergology, Uppsala University started in 2013. 
The aim of the study is to find clinical tools for identifying patients with risk for COPD exacerbations. This is a regional study aiming to include 600 COPD patients in the counties of Uppsala, Gävleborg and Dalarna. Recruitment started in May 2014 and patients will be studied during two years with three visits including examinations, blood analysis and questionnaires.  
Two abstracts have been accepted at the IPCRG Congress in 2016. Three abstracts have also been submitted to the ERS congress in 2016 and several manuscripts are under preparation. 

Illustrativ bild.