Group leader: Martin Ingelsson
Visiting address: Dag Hammarskjölds väg 20, Uppsala Science Park
The aim of our research is to understand, prevent, diagnos and cure diseases in the elderly population, like dementia, diabetes and cardiovascular diease.
In clinical trials we develop new drugs against these diseases. We are conducting epidemiological and genetic studies to understand the interplay between genes and environment in complex disorders. In clinical research we aim to develop better diagnostic instruments for Alzheimer’s disease. Our molecular research is aiming at disease mechanisms of Alzheimer’s disease and related disorders. The starting point for these studies is genetic discoveries to understand molecular mechanisms involved in dementias. Model systems have been developed in transgenic animals and in cell cultures to test new treatment principles.
News
Latest Publications
- Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes. 2019
- Chemical imaging of evolving amyloid plaque pathology and associated A beta peptide aggregation in a transgenic mouse model of Alzheimer's disease.
- Genetic predisposition to mosaic Y chromosome loss in blood.. 2019
- Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals. 2019
- SPISE and other fasting indexes of insulin resistance: risks of coronary heart disease or type 2 diabetes. Comparative cross-sectional and longitudinal aspects.
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 2019
- High levels of AAV vector integration into CRISPR-induced DNA breaks. 2019
- Outcome-Driven Thresholds for Ambulatory Blood Pressure Based on the New American College of Cardiology/American Heart Association Classification of Hypertension. 2019
- A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study. 2019
- Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 2019
Latest Theses
- Independent Ageing in Very Old Swedish Men. 2019
- Cellular responses to amyloid-beta protofibrils: Focus on astrocytes, extracellular vesicles and antibody treatment. 2018
- Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment. 2017
- Therapeutic and functional studies in animal models of Alzheimer's disease. 2014
- Physical Activity and Alzheimer's Disease: Measurements, Observations and Subjective Experiences. 2014
- The Kidney in Different Stages of the Cardiovascular Continuum. 2013
- Prostate Cancer; Metabolic Risk Factors, Drug Utilisation, Adverse Drug Reactions. 2013
- Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease. 2011
- Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease. 2010
- Aβ Conformation Dependent Antibodies and Alzheimer's Disease. 2010